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聚集性感染家族內乙型肝炎病毒標志物
作者：何英利，趙英仁，高珩，張樹林，楊瑗，陳蕓茹，劉錦峰【關鍵詞】 ,肝炎病毒,乙型；家族聚集性；疾病易感性
【Abstract】 AIM: To determine the spread of HBV virological profile of Chinese clustering infected families with threegeneration genetic information. METHODS： All the patients who referred to our department were questioned for HBV family history from 2002 to 2005. For those families with threegeneration or more genetic information, their blood were drawn after signed informconsents were obtained and tested for hepatitis B surface antigen (HBsAg), antibody to HBsAg (antiHBs), hepatitis Be antigen (HBeAg), antibody to HBe（antiHBe） and antibody to hepatitis B core antigen (antiHBc) using commercially available enzymelinked immunosorbent assay(ELISA). HBV genome copies in serum were tested by realtime quantitive PCR. The first member of a family identified as a virus carrier was considered an index case. All study subjects were asked to fill out a questionnaire designed by Epiinfo software on general data, history, results of serologic analysis, and kinship to the index case. All the data of each subject was input into computer for statistic analysis. RESULTS： A total of 237 serum samples of 27 familes were tested. Out of 237 index cases and household contact subjects, 45.6%, 5.9%, 26.7%, 11.8%, 62.9%, 28.3% subjects were identified HBsAg, antiHBs, HBeAg, antiHBe, antiHBc, HBV DNA positive respectively. The patients with positive HBV DNA, HBeAg or HBsAg were predominantly male and the mumber peaked at the age of 18 and 45 years old. CONCLUSION： The seroprevalence of HBV markers in clustering infected family is different from that in general population; the infected individuals have a natural course of chronic HBV infection and mostly are infected as they are infants, which is probably associated with host genetic susceptibility to HBV.
【Keywords】 hepatitis B virus; family clustering; disease susceptibility
【摘要】目的： 研究HBV 血清標志物及HBV DNA在聚集性感染家族內的流行模式. 方法： 以2002/2005在我院感染科就診的來自偏遠山區的HBsAg陽性者為先證者，詢問其家族史，篩選具有3代或以上遺傳信息的家系. 簽署知情同意書后，對這家系中所有的人進行流行病學調查，收集血樣. 用ELISA檢測HBsAg，抗HBs，HBeAg，抗HBe，抗HBc；用RealTime PCR 定量檢測HBV DNA. 結果： 共收集27個家系237人；HBsAg，抗HBs，HBeAg，抗HBe，抗HBc，HBV DNA的總體陽性率分別為45.6%，5.9%，26.7%，11.8%，62.9%，28.3%；在HBV聚集性感染家族中，男性的HBsAg，HBeAg，HBV DNA的陽性率顯著高于女性；HBsAg及HBV DNA相對年齡成雙峰分布，主要集中在18歲和45歲. 結論： 在聚集性感染家族中，HBV的流行病學資料有其自身特點；家族聚集性感染者符合慢性HBV感染的自然病程，多為嬰幼兒期感染所致，可能與宿主的遺傳易感性有關.
【關鍵詞】 肝炎病毒，乙型；家族聚集性；疾病易感性
0引言
我國是HBV高發區. 早期的研究發現HBV感染呈家族聚集
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