心肌梗死大鼠心臟ACE2基因的表達意義

心肌梗死大鼠心臟ACE2基因的表達意義

作者：陳高，黃從新，趙慶彥，姚艷

【關鍵詞】 大鼠；ACE2,mRNA；心肌梗死
　　Expression of ACE2 mRNA in rat myocardium after acute myocardial infarction and its significance
　　【Abstract】 AIM: To investigate the changes of the mRNA expression of ACE2 after acute myocardial infarction (AMI) in SD female rat. METHODS: Thirtysix SD female rats were randomly separated into 3 groups (n=12 in each one) according to the infarction duration (1, 3, 28 d), which were randomly and evenly again separated into 2 subgroups: operated group and sham operated group. The levels of mRNA expression of ACE2 in the noninfarct and infract area of left ventricle 1, 3, 28 d after AMI were detected by RTPCR and analyzed semiquantitatively by imageanalysis system. RESULTS: Compared with sham operated group, the mRNA expression of ACE2 had no significant difference in the infract and noninfarct areas of operated group at day 1 after AMI (P

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